For US Healthcare Professionals Only
For US Healthcare Professionals Only
Significantly more patients
Patients on Jakafi demonstrated significantly higher rates of complete hematologic remission (CHR)* vs BAT1
(26/110) of patients receiving Jakafi achieved CHR at week 32 vs 8% (9/112)
of patients receiving BAT (P=0.0016)1†
Individual component of CHR
Jakafi reduced mean WBC counts
It’s important in patients with polycythemia vera to establish what their baseline white blood cell count is. Ideally, we want this number to be at or below 11,000 because we understand there’s some risk associated with a higher baseline white blood cell count.
HEAR FROM DR KUYKENDALL ABOUT
THE IMPORTANCE OF WBC MANAGEMENT
Exploratory analyses from the RESPONSE trial: WBC count data
From The New England Journal of Medicine, Vannucchi AM, Kiladjian JJ, Griesshammer M, et al, Ruxolitinib versus standard therapy for the treatment of polycythemia vera, 372, 426-435. Copyright © 2015. Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.
Comprehensive haematological control with ruxolitinib in patients with polycythaemia vera resistant to or intolerant of hydroxycarbamide, Harrison CN, Griesshammer M, Miller C, et al. Copyright © 2018 John Wiley & Sons Ltd, British Journal of Haematology. Reproduced with permission of John Wiley & Sons Ltd.
*CHR was defined as achieving Hct control (as specified in the primary endpoint), platelet count ≤400 × 109/L, and WBC count ≤10 × 109/L.1
†Jakafi: 95% CI, 0.16-0.33; BAT: 95% CI, 0.04-0.15.1
BAT=best available therapy; CI=confidence interval; Hct=hematocrit; HU=hydroxyurea; MF=myelofibrosis; MPN=myeloproliferative neoplasm; PV=polycythemia vera; RESPONSE=Randomized study of Efficacy and Safety in POlycythemia vera with JAK iNhibitor ruxolitinib verSus bEst available care; WBC=white blood cell.
References: 1. Jakafi [package insert]. Wilmington, DE: Incyte Corporation. 2. Kiladjian J-J, Zachee P, Hino M, et al. Long-term efficacy and safety of ruxolitinib versus best available therapy in polycythaemia vera (RESPONSE): 5-year follow up of a phase 3 study. Lancet Haematol. 2020;7(3):e226-e237. Supplementary appendix available at: doi:10.1016/S2352-3026(19)30207-8. 3. Data on file. Incyte Corporation. Wilmington, DE. 4. Vannucchi AM, Kiladjian JJ, Griesshammer M, et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015;372(5):426-435. Supplementary appendix available at: https://www.nejm.org/doi/suppl/10.1056/NEJMoa1409002/suppl_file/nejmoa1409002_appendix.pdf. 5. Harrison CN, Griesshammer M, Miller C, et al. Comprehensive haematological control with ruxolitinib in patients with polycythaemia vera resistant to or intolerant of hydroxycarbamide. Br J Haematol. 2018;182(2):279-284. Supplemental information available at: https://onlinelibrary.wiley.com/doi/10.1111/bjh.14764.
Indications and Usage
Jakafi® (ruxolitinib) is indicated for treatment of polycythemia vera (PV) in adults who have had an inadequate response to or are intolerant of hydroxyurea.
Jakafi is indicated for treatment of intermediate or high-risk myelofibrosis (MF), including primary MF, post–polycythemia vera MF and post–essential thrombocythemia MF in adults.
Jakafi is indicated for treatment of steroid-refractory acute graft-versus-host disease (aGVHD) in adult and pediatric patients 12 years and older.
Jakafi is indicated for treatment of chronic graft-versus-host disease (cGVHD) after failure of one or two lines of systemic therapy in adult and pediatric patients 12 years and older.
Important Safety Information
Please see Full Prescribing Information for Jakafi.
Indications and Usage
Jakafi® (ruxolitinib) is indicated for treatment of polycythemia vera (PV) in adults who have had an inadequate response to or are intolerant of hydroxyurea.
Jakafi is indicated for treatment of intermediate or high-risk myelofibrosis (MF), including primary MF, post–polycythemia vera MF and post–essential thrombocythemia MF in adults.
Jakafi is indicated for treatment of steroid-refractory acute graft-versus-host disease (aGVHD) in adult and pediatric patients 12 years and older.
Jakafi is indicated for treatment of chronic graft-versus-host disease (cGVHD) after failure of one or two lines of systemic therapy in adult and pediatric patients 12 years and older.
Important Safety Information
Please see Full Prescribing Information for Jakafi.