Steroid-refractory aGVHD may progress rapidly from diagnosis to maximum grade1
An Incyte-Sponsored Retrospective Chart Review of 168 Patients With Grade 2 to 4 SR/SD aGVHD1*

- *A multicenter, retrospective chart review conducted at 11 large US academic and community transplant centers in patients with grade 2 to 4 SR/SD aGVHD who had their first hematopoietic cell transplantation between January 2014 and June 2016.1


I would suggest considering Jakafi at the first sign of steroid-refractory acute GVHD.
Michael R. Bishop, MD
GVHD Expert


Cell images from McDonald-Hyman C et al. Sci Transl Med. 2015;7(280):280rv2. doi:10.1126/scitranslmed.aaa6853. Other images from Getty Images.
aGVHD=acute graft-versus-host disease; APC=antigen-presenting cell; GI=gastrointestinal; NK=natural killer; REACH=Ruxolitinib in patiEnts with refrACtory graft-versus-Host disease after allogeneic stem cell transplantation; SD=steroid dependent; SR=steroid refractory; Treg=regulatory T cell.
References: 1. Holtan SG, Yu J, Paranagama D, et al. Disease progression, hospital readmissions, and clinical outcomes for patients with steroid-refractory acute graft-versus-host disease: a multicenter, retrospective study. Bone Marrow Transplant. 2022;57(9):1399-1404. 2. McDonald-Hyman C, Turka LA, Blazar BR. Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation. Sci Transl Med. 2015;7(280):280rv2. doi:10.1126/scitranslmed.aaa6853. 3. Ferrara J, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet. 2009;373(9674):1550-1561.