Dose Modifications of Jakafi for Elevated Total Bilirubin1
Elevated Total Bilirubin Without Liver GVHD
- 3.0−5.0 × ULN: continue at 1 dose level lower until recovery
- >5.0−10.0 × ULN: hold for up to 14 days until ≤1.5 × ULN; resume at current dose upon recovery
- >10.0 × ULN: hold for up to 14 days until ≤1.5 × ULN; resume at 1 dose level lower upon recovery
Elevated Total Bilirubin With Liver GVHD
- >3.0 × ULN: continue at 1 dose level lower until recovery
GVHD, graft-versus-host disease; ULN, upper limit of normal.
See Full Prescribing Information for further details on dose modifications and use in special populations.
Reference
Jakafi Prescribing Information. Wilmington, DE: Incyte Corporation.