When do you intervene in patients with intermediate- or high-risk MF?
MF is a serious disease that may require active management at diagnosis.1


aFive-year overall survival rates were estimated using SEER data obtained from population-based cancer registries of the US population and SEER*Stat Software version 8.3.2. The analysis included patients with initial/primary site diagnosis between years 2007-2011. Overall survival is defined as the time from diagnosis until death from any cause.
In MF, the presence of any of the following risk factors* indicates that a patient is already intermediate risk3,4:
- Hemoglobin level <10 g/dL
- Leukocyte count >25 × 109/L
- Age >65 years
- Red cell transfusion dependency
- Circulating blast cells ≥1%
- Platelet count <100 × 109/L
- Constitutional symptoms
- Unfavorable karyotype
*As included in the Dynamic International Prognostic Scoring System Plus tool.